Male
extra tasting ability
rare T allele, better at detecting umami taste
Influences tasting ability. This blog entry discusses the research. the rare T allele of rs307377(T) (R757C) in TAS1R3 led to a doubling of umami ratings of 25 mmol MPG/L. Other suggestive SNPs of TAS1R3 include the A allele of A5T and the A allele of R247H, which both resulted in an approximate doubling of umami ratings of 200 mmol MPG/L ... more info...
fully heterozygous, age related tasting variation you are heterozygous at all 3 of the SNPs which are known to influence the ability to taste bitterness. This means you are better than average at detecting bitter tastes while young, but that this ability will decrease to less than average during adulthood. As a child you will probably hate brussel sprouts, and by early adulthood will discover that olives and brussel sprouts now taste good. A 2010 study shows the change bitter sensitivity which occurs over the lifespan (from bitter sensitive to less so) is more common in people with this genoset. Children with this genotype could perceive a bitter taste at lower PROP concentrations than could heterozygous adults. The threshold for adolescents was intermediate. The 3 SNPs are rs10246939, rs1726866, rs713598 in the gene TAS2R38.
possible increased risk of breast cancer one of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for breast cancer
rs6983267 is a SNP on chromosome 8q24, associated with increased risk for several cancers, particularly prostate cancer. In studies dividing the 8q24 region, this SNP falls in region 3. This SNP has also been reported to influence the cancer-risk-decreasing effect of aspirin. In a study of over 3,600 Caucasians with prostate cancer, rs6983267 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs6983267(G;G) and (G;T) risk genotypes yield an odds ratio for developing prostate cancer of 1.37 (CI: 1.18-1.59, p=3.4-10e-5) and may account for 22.2% of population attributable risk. The increased risk of developing prostate cancer associated with rs6983267 now appears to be independent of the risk associated with its close neig... ... more info...
increased risk of breast cancer g risk allele
unlikely to think cilantro tastes like soap rs7107418 g allele is associated with lower chances of thinking cilantro tastes like soap
rs738409 is a SNP in the PNPLA3 gene. In all HapMap populations the most common allele is a G on the positive strand. In the scientific literature, the less common C allele is considered normal, and linked to lower liver fat content. In a Mestizo population, rs738409 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted odds ratio 2.25, p=1.7 x 10(-10); ancestry-adjusted OR 1.79, p=1.9 x 10(-5)). rs738409(G) increased quantitative measures of liver fat content nature Nonalcoholic fatty liver disease. Fat content 2x for rs738409(G;G) rs738409(G) (I148M) was strongly associated with increased hepatic fat levels (P = 5.9 times 10-10) [PharmGKB:Curated In a genome-wide association study this SNP in PNPLA3 gene was strongly associated with i... ... more info...
~0.4cm taller each C allele increased height by 0.4cm
increased risk of male pattern baldness one copy of risk allele and one copy of the normal allele. Verified in Europeans and Asians.
Two SNPs from chromosome 4q25, rs2200733 and rs10033464, were found to be associated with atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x. In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs10033464 was associated with cardioembolic stroke (CES) (odds ratio 1.27, p = 6.1 x 10e-4). rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent. Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation. Common variants in KCNN3 are associated with lone atrial fibrillation. Associ... ... more info...
| Bad | Repute |
| 3 | Magnitude |
| plus | Orientation |
| 27.7% | Frequency |
| 0.1047 | GMAF |
| 19 | References |
| 6 | Chromosome |
| 137685367 | Position |
| 3.5 | Max Magnitude |
| 20141108 | Rs time |
1.2x risk Rheumatoid Arthritis
...more...rs6920220 has been reported in a large study to be associated with rheumatoid arthritis. The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.20 (CI 1.06-1.36), and for homozygotes, 1.72 (CI 1.33-2.22). rheumatoid arthritis *rs6920220 [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)]. *rs5029937 *rs13207033 protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with rs10499194 The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85) Lack of association or interactions between the IL-4, IL-4Ralpha an... ... more info...
| Bad | Repute |
| 3 | Magnitude |
| minus | Orientation |
| 38.1% | Frequency |
| 0.2392 | GMAF |
| 0 | References |
| RNASEL | Gene |
| 1 | Chromosome |
| 182586901 | Position |
| 3 | Max Magnitude |
| 20140530 | Rs time |
1.5x - 2x increased risk for cervical cancer, HNSCC, and breast cancer
...more...rs3738579 represents a SNP in the 5' UTR region upstream of the RNASEL gene. A study of patients diagnosed with carcinoma of the uterine cervix, head and neck squamous cell carcinomas (HNSCC), and breast cancer found 1.5x-2x increased risk for all three cancer types for the rs3738579(T;T) genotype, while finding decreased risk (0.5x) for rs3738579(C;T) heterozygotes. rs3738579(C;C) homozygotes had 0.6x less risk for cervical cancer but increased risk for HNSCC (1.4x) and breast cancer (1.8x). Although statistics were not reported per genotype, a combination of data from all three cancer forms over all genotypes provided strong statistical evidence for rs3738579 as a cancer marker, with a p-value of 4.43×10e−5. ... more info...